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Search Results for " il-21 receptor "

Targets Recommended: Glucocorticoid Receptor Others Interleukin

2

抑制剂 & 化合物

6

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T4602	Hydrocortisone hemisuccinate Hydrocortisone 21-he,氢化可的松琥珀酸酯,hydrocortisone 21-hemisuccinate*free acid,Hydrocortisone 21-hemisuccinate	Glucocorticoid Receptor; Others; Interleukin	Endocrinology/Hormones; Immunology/Inflammation; Others
	Hydrocortisone hemisuccinate (hydrocortisone 21-hemisuccinate*free acid) 是糖皮质激素，是口服有活性的甾体抗炎剂。它能够降低IL-6(IC50:6.7 μM)、IL-3(IC50:21.4 μM)的生物活性，可用于研究溃疡性结肠炎。
T35836	PMX-205 (trifluoroacetate salt)
	PMX-205 is a cyclic hexapeptide that acts as a potent antagonist of C5a receptor (C5aR; IC50= 31 nM).1It is orally active and blocks inflammatory signaling and symptoms in animal models of colitis and allergic asthma.2,3PMX-205 is also brain penetrant and reduces neuroinflammation and neurodegeneration in an animal model of Alzheimer's disease.4 1.March, D.R., Proctor, L.M., Stoermer, M.J., et al.Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes. Rela...

化合物

Hydrocortisone hemisuccinate

Cat.No: T4602

Synonym: Hydrocortisone 21-he,氢化可的松琥珀酸酯,hydrocortisone 21-hemisuccinate*free acid,Hydrocortisone 21-hemisuccinate

Target: Glucocorticoid Receptor, Others, Interleukin

PMX-205 (trifluoroacetate salt)

Cat.No: T35836

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-01337	IL-21R Protein, Mouse, Recombinant (aa 20-236, His) Nilr,IL-21R,Interleukin-21	Mouse	HEK293 Cells
	Interleukin-21 receptor (IL-21R) is a type I transmembrane glycoprotein within the class I cytokine receptor family, type 4 subfamily. IL-21R is expressed mainly on B cells, NK cells, and activated T cells, but is also found on dendritic cells, alternatively activated macrophages, intestinal lamina propria fibroblasts and epithelial cells, and keratinocytes. Both IL-21 and IL-4 are necessary for efficient B cell IgG1 production and normal germinal center architecture. B cell IL-21 R engagement i...
TMPK-00668	IL-21R Protein, Cynomolgus, Recombinant (aa 41-254, His) NILR,IL-21 receptor,...	Cynomolgus	HEK293 Cells
	IL-21 and IL-21R were highly expressed in the lesional skin and peripheral blood of psoriasis patients. IL-21 promoted CD4 T cells proliferation and Th17 cells differentiation and inhibiting Treg cells differentiation by upregulating RORγt expression and downregulating Foxp3 expression, with increased expression and secretion of IL-17A and IL-22.Microbial translocation and the associated immune activation during HIV-1 infection may lead to high expression levels of the IL-21R activation marker i...
TMPJ-01316	IL-21 Protein, Mouse, Recombinant (His) 白细胞介素,IL-21,Interleukin-21,白介素,	Mouse	E. coli
	Interleukin-21(IL-21) is an approximately 14 kDa cytokine which belongs to the IL-15/IL-21 family. Mature mouse IL-21 shares 66%,59%, 58%, and 88% aa sequence identity with mature canine, human, rabbit, and rat IL-21, respectively. IL-21 is produced by activated T follicular helper cells (Tfh), Th17 cells, and NKT cells. It exerts its biological effects through a heterodimeric receptor complex (IL-21 specific IL-21 R). IL-21 is a cytokine that has potent regulatory effects on cells of the immun...
TMPK-01111	LILRB1/CD85j/ILT2 Domain1 & 2 Protein, Human, Recombinant (His) CD85J,XXbac-BCX85G21.4,LILRB1,ILT...	Human	HEK293 Cells
	LILRB1, also known as CD85j and IL-T2, is a 110 kDa transmembrane glycoprotein in the LILR immunoregulatory protein family. Mature human LILRB1 consists of a 438 amino acid (aa) extracellular domain (ECD) with 4 tandem Ig-like domains, a 21 aa transmembrane segment, and a 168 aa cytoplasmic domain with 4 inhibitory ITIM motifs.LILRB1 is a receptor for class I MHC antigens. LILRB1/CD85j/ILT2 Domain1 & 2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The p...
TMPK-01110	LILRB1/CD85j/ILT2 Protein, Human, Recombinant (aa 116-461, His) ILT-2,XXbac-BCX85G21.4,MIR7,ILT2F...	Human	HEK293 Cells
	LILRB1, also known as CD85j and IL-T2, is a 110 kDa transmembrane glycoprotein in the LILR immunoregulatory protein family. Mature human LILRB1 consists of a 438 amino acid (aa) extracellular domain (ECD) with 4 tandem Ig-like domains, a 21 aa transmembrane segment, and a 168 aa cytoplasmic domain with 4 inhibitory ITIM motifs.LILRB1 is a receptor for class I MHC antigens. LILRB1/CD85j/ILT2 Protein, Human, Recombinant (aa 116-461, His) is expressed in HEK293 mammalian cells with C-His tag. The p...
TMPY-00351	FGFR2 Protein, Human, Recombinant (beta IIIc, His) fibroblast growth factor receptor 2,TK14,FGFR2 Prot...	Human	HEK293 Cells
	FGFR2 Protein, Human, Recombinant (beta IIIc, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31.2 kDa and the accession number is P21802-21.

重组蛋白

IL-21R Protein, Mouse, Recombinant (aa 20-236, His)

Cat.No: TMPJ-01337

Species: Mouse

Expression System: HEK293 Cells

IL-21R Protein, Cynomolgus, Recombinant (aa 41-254, His)

Cat.No: TMPK-00668

Species: Cynomolgus

Expression System: HEK293 Cells

IL-21 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01316

Species: Mouse

Expression System: E. coli

LILRB1/CD85j/ILT2 Domain1 & 2 Protein, Human, Recombinant (His)

Cat.No: TMPK-01111

Species: Human

Expression System: HEK293 Cells

LILRB1/CD85j/ILT2 Protein, Human, Recombinant (aa 116-461, His)

Cat.No: TMPK-01110

Species: Human

Expression System: HEK293 Cells

FGFR2 Protein, Human, Recombinant (beta IIIc, His)

Cat.No: TMPY-00351

Species: Human

Expression System: HEK293 Cells

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